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HPV & Cervical Cancer
In regions where women do not have access to regular check-ups, cervical cancer is a leading cause of death. In many places, the Pap test is used to detect cervical cancer; this outdated method was introduced in the 1940s, and because of its low accuracy it is now often replaced by HPV testing. Nearly all cervical cancers are caused by HPV infection, but only a very small number of women who have HPV will develop cervical cancer. For example, in the US, more than 20% of women have HPV, but less than 0.5% will develop cervical cancer. A positive HPV test alone can therefore lead to unnecessary anxiety, and to unnecessary treatments. Identifying which high-risk HPV infections will lead to cancer has historically been a diagnostic challenge. It is now known that HPV produces two oncoproteins, E6 and E7, without which cancer does not occur.
Detection of HPV DNA or RNA simply identifies infection. Detection of the E6 and/or E7 oncoproteins, however, provides a means of identifying the transition from infection toward cancer. Arbor Vita’s OncoE6™ Cervical Test offers a solution to this problem: the OncoE6™ Cervical Test directly detects the cancer-causing E6 oncoprotein molecule, made by those few HPV infections that will cause cervical cancer with a high likelihood.
Arbor Vita’s OncoE6™ product line identifies patients that are not only infected with HPV but are also producing E6 oncoproteins, indicating the presence of cervical pre-cancerous or cancerous lesions.
With its dipstick-like format, OncoE6™ is simple, quick, non-invasive, and requires no refrigeration. The test is compatible with specimens collected from either a regular Pap smear or liquid Thinprep© (see OncoE6™ Liquid Specimen Preparation Kit).
OncoE6™ Cervical Test – CE-IVD
The OncoE6™ Cervical Test is a rapid and easy-to-use lateral flow assay based on the detection of E6 oncoproteins. The OncoE6™ Cervical Test is available in the US, as a service through our CLIA-certified laboratory.
OncoE6™ Cervical Test Liquid Specimen Preparation Kit – CE-IVD
In addition to cervical swabs, detection of E6 oncoproteins can be achieved using liquid based cervical cytology specimens. Arbor Vita Corporation has developed the OncoE6™ Cervical Test Liquid Specimen Preparation Kit that can be used to pre-process specimens stored in Hologic ThinPrep© PreservCyt©.
OncoE6™ Cervical Test Starter Kit – CE-IVD
The Starter Kit contains accessories to help with smooth running of the OncoE6™ Cervical Test, including simple reference guides.